The report makes a significant attempt to address an important issue.

It is not only a moral issue health inequalities carry significant economic costs.

Meanwhile, ordinary citizens do not notice unless the issue receives significant media attention.

Those proposals, which address the heart of the issue, constitute a significant development.

The independent expert did not observe any significant progress on the issue of impunity.

While the international community has given the issue significant attention, it is not enough.

But the most significant issue coming to the fore in hemispheric relations is immigration. Traditionally a Mexican, Central American, and Caribbean matter, it has now reached Brazil, Colombia, Venezuela, Ecuador, and beyond.

There remains the most fundamental issue of attitude.

Consider China, by many measures the most significant emerging country.

Like most committee chairs, they have significant agenda setting power.

Dublin was the most significant settlement in the long term.

Longlines are the most significant threat to these species' survival.

The issue most prominent in the submissions related to documentation.

This issue is the most important item on our agenda.

A significant issue is the scope of the taxes to be covered by the exchange of information clause.

It was one of the most significant laws of pre war Japan.

Among these, one of the most significant was 230(o), which stated

The most significant aspects of the Money Laundering Act are as follows

When respondents are asked what the most important problem facing the country is, they answer with the most accessible news issue in memory, which is typically the issue the news media focused on the most.

And society must bear significant additional costs in terms of the risks of spent fuel storage and large scale accidents. Moreover, in most parts of the world where energy consumption is expanding, nuclear proliferation is an issue.

The government's land distribution is perhaps the most crucial and most bitterly contested political issue surrounding Zimbabwe.

This is the most delicate issue of all for South Korea.

Most important, significant gains in health could be attained with adequate financial resources.

The most significant problem would be capital losses for core eurozone financial institutions.

This is, by far, one of the most significant I have ever seen.

Satellite imagery of the most significant sites continues to be collected and assessed.

Mr. Fahey (Ireland) said that, following the Government's adoption in 2000 of new childcare standards as a way of encouraging women to work, childcare had quickly become the most significant issue in relation to the employment of women.

The issue of human rights in Canada has not attracted significant controversy relative to human rights issues in other countries.

We were also pleased to observe that this significant issue was duly addressed in the United Nations summit outcome document.

In most networks around the world this is no longer an issue.

In most people's minds, the issue of Minamata disease had been resolved.

They organize its meetings. Like most committee chairs, they have significant agenda setting power.

But transfers from the African diaspora stand out as the most significant contributing factor.

Children burdened by significant economic insecurity, discrimination, or maltreatment benefit most from effective interventions.

The new approach to exchange rate policies represents one of the most significant advances.

To make the most of it requires a significant boost in mutual strategic trust.

In the past, Alneda.com and Jehad.net were perhaps the most significant al Qaeda websites.

The most significant difference across categories of mental health practitioners is education and training.

More telling, the countries that cut expenditure the most experienced the largest bond yield spikes and the most significant debt growth.

But looking at the question in this way raises another, and perhaps more significant, issue about virtual activities video game violence.

Unfortunately, most European governments merely shrug their shoulders when the issue is raised.

Voting on such an issue is the most obvious way of resolving it.

Indeed, such guarantees constitute the most significant medium and long term financial risks to China.

Representatives welcomed the report of the workshop, dealing as it did with an issue of significant importance, particularly for many developing countries.

Among the priority areas, HIV AIDS is no longer treated as just a health issue, but as a most serious socio economic development issue.