Two serious problems make reconciliation in Afghanistan particularly challenging.

This category is especially useful for solving especially challenging problems.

The large countries in this part of the Islamic world most notably Egypt, Pakistan, and Turkey are attempting to address four problems, the most challenging of which is to define Islam s role in the political system.

Most should be able to grow strongly, despite the challenging global environment.

Of these three imperatives, sustainability may be the most complex and challenging.

The most difficult things to X ray, the most technically challenging things to X ray are the lightest things, the most delicate things.

But, following monetary easing and fiscal expansion, it is Abenomics third arrow that will prove most important and most politically challenging.

After all, host countries have been able to contain nuclear risks in the most challenging circumstances.

PM What's the best part of working with your mother, and the most challenging part for you?

Most of Nigeria s problems are well known.

Beyond coordination, the requirement to build sustainable capacity is one of the most significant issues challenging technical cooperation activities.

But, owing to China s skewed economic structure, its exchange rate regime presents much more challenging problems than those encountered by Japan and other East Asian economies.

And this shows that engineers, medical people, scientific people, have an obsession with solving the problems of reality, when actually most problems, once you reach a basic level of wealth in society, most problems are actually problems of perception.

Reform of the security sector has therefore been one of the most important and challenging items on the institutional agenda.

The most serious problems right now are in Europe.

Most people with this condition also experience visual problems.

It is one of the most challenging race tracks in the world, mainly due to its fast, hilly and twisty nature.

The deployment and use of this seismic network is considered one of the most challenging aspects of the Don Quijote mission.

And when I see the power that dispersal has on these biogeographic patterns, it makes me think that it's possible to tackle really challenging problems, like hospital acquired infections.

A bit more challenging, right?

Most of the seemingly intractable problems would vanish into thin air.

Many, probably most, of the other problems were managerial in nature.

The Secretary General has described the response to the South Asian earthquake as the most challenging relief operation ever faced by the United Nations.

A bit more challenging, right? (Laughter)

Because it's by challenging the way things are always done is that we are able to break out of the rut that we're in and create innovative solutions to problems of today.

One reason is that the most urgent business problems for reasons of profitability and competitiveness were primarily accounting problems, such as billing.

MASSOB, rightly aggrieved that no real effort has been made by successive Nigerian leaders to tackle the Igbo region s economic and political problems, is still challenging the central government s authority in the region.

The rising trend of illicit drug abuse, production and trafficking remained one of Indonesia's most serious problems. What was becoming more challenging was the fact that Indonesia was no longer targeted as a mere transit country but was considered a destination for the sale of illicit drugs and production of synthetic drugs.

But striking the proper balance is challenging.

That will be particularly challenging for Bernanke.

That is an assumption that needs challenging.

Emerging and challenging issues deriving from implementation

Europe is currently facing its most challenging crisis of the postwar period. After six quarters of recession, the slump is spreading to the eurozone s core countries.

Access to the visual history of most former colonial countries in Africa is usually a challenging proposition because former colonial powers restrict access to historical archives.

The most important problems are drinking and irrigation water, and internal communication roads.

Some of the most commonly shared symptoms include fatigue, skin problems or acne, mood swings, weight problems, diminished sex drive, and no memory.

Ironically, Germany might provide the most useful template for the problems facing US policymakers.

Land access and profit repatriation remained two of the most urgent problems in Algeria.

It plays a major role in solving the most urgent problems of modern times.

Finally, Japan s external environment today is more challenging.

However, the situation in Cité Soleil remains challenging.

During most visits he had complaints concerning his general health, including a bad back, gastric ulcer, kidney infection and thyroid problems, causing, inter alia, sleeping problems.

But most of those in Davos put aside these problems to celebrate the euro s survival.

But success in Cairo might prove even more challenging.

This means that Europe probably faces another challenging year.