Unrepaired single strand breaks are not very toxic to cells.

However, these breaks disrupt and damage the DNA when they are copied as DNA replicates.

Despite some interruptions (such as the Avignon papacy), Rome has for centuries been the home of the Roman Catholic Church and the Bishop of Rome, otherwise known as the Pope.

Chemical inhibition of the PARP1 protein results in reduced occurrence of these single strand break repairs.

Sami made friends with many physicians.

Barzani went to Iran with many of his supporters.

Many writers and journalists interacted with the idea of the bloggers, and in turn wrote many articles to support the campaign.

Sami had a lot of mutual friends with Layla.

It included good diplomatic relationships with many Western countries.

Many Greek cities are allied with one or the other.

Architecture There are many different ways to design a network with a DMZ.

There was a paved courtyard with many small, off shoot rooms.

Many former Norwegian Army members also served with the German forces.

The language shares many features of dataflow programming languages.

The match began with multiple aerial tactics and many pin attempts.

I had plenty of time to talk to many friends.

Globalization has been good to many in the developing world.

We can treat many things, even packages, like individuals.

A number of missions are also located in the city, providing schools and hospitals.

Many local residents came to take photographs with the plaque and tree.

The modification involves replacing a face plate with many small protruding tubes with one that is flat.

Many with common interests.

Sadly, many other crises continue to suffer from neglect.

The chemical inhibitors used in this treatment target the enzyme polymerase (PARP1), which is normally involved in the repair of DNA single strand breaks a common form of spontaneous DNA lesions.

Many younger Japanese have told me that they are fed up with stagnation and drift.

With higher energy prices, many Russian officials are enjoying their renewed power.

He also drove various proposals for regional integration in Latin America and the Caribbean.

Akrami spent five years interviewing a dozen Iranian filmmakers, actors and actresses.

However, as with many rules of thumb, there are many caveats and exceptions.

In this work, he describes many of his experiments with his model Earth called the terrella.

The coast is also intersected by numerous rivers, the largest of which is the Mississippi River.

We note with appreciation the response of the many countries that have given assistance to the victims of the tsunami.

This is an area of classical glaciokarstic landscape, with numerous glacial trough valleys and cirques, with ridges and peaks between them.

While these issues have complicated the lives of many Syrian refugees, it is also true that many Syrian refugees are calling Brazil home, with many finding established communities helping them integrate.

And so this has raised a bunch of problems for them when dealing with these sorts of issues.

We've discovered with AIDS we need cocktails to work well so that the viral resistance we need several anti virals.

However, whilst some Chinese citizens are in celebratory mood over these construction achievements, many are worried about the 'skyscraper curse'.

This has led Williams, in particular, into several run ins with the media.

Numerous policy options to deal with this problem are now being debated.

However, many humanitarian organizations are determined to remain in Pakistan despite the attacks.

There has also been a lot of visual creativity, with protesters creating posters, painting helmets, tents, etc.

With the adoption of the hymn by the ANC as its official anthem, the song was sung at many official events.

The airport is also serviced by various oil companies with corporate and charter flights.

Numerous flat topped buttes with rich soil stand high above the chaotic scablands.

But cells with mutated BRCA1 or BRCA2 genes are unable to undergo recombination and are therefore much more sensitive to an increased level of unrepaired single strand breaks.