Now it turns out that in Alzheimer's disease, there's a huge deficit in glucose utilization in the brain.

Glucose has been split.

It lyses the glucose.

We then put in the DBS electrodes and we wait for a month or a year, and the areas in red represent the areas where we increase glucose utilization.

The glucose in the blood reacts with an enzyme electrode containing glucose oxidase (or dehydrogenase).

So the whole point is really to go from glucose, from one mole of glucose

Glucose is the energy source.

Maybe glucose will bond here.

And glucose is indeed sweet.

This is glucose right here.

Glucose was our starting point.

The liver helps regulate glucose levels by reducing its secretion of glucose in the presence of insulin.

Any excess glucose stimulated the pancreas to release insulin, which transported glucose into peripheral fat tissue, and which also caused the liver to store glucose as glycogen (liver starch).

And glucose, we know its formula.

Over here we have our glucose.

It's taking glucose for the ride.

So that's your glucose right there.

Which literally means breaking up glucose.

In most organisms, glucose is the most important substrate of hexokinases, and glucose 6 phosphate the most important product.

And so essentially glucose concentration will go up high here, and then if we make this porous to glucose so glucose can go through, then glucose will eventually, if this gets high enough, it'll just go down its concentration gradient eventually into the blood.

We're starting with a glucose right there.

I'll just do the example of glucose.

So that's what glucose actually looks like.

You've got glucose and oxygen going in.

It is a type of glucose clamp technique.

It's more likely too much glucose blood sugar.

Glucose got split into two of these guys.

We started off with 12 hydrogens in glucose.

It's taking so much glucose from my bloodstream.

Let's think about what happens with the glucose.

To determine blood glucose, the measuring beam of infrared light, for example, has to penetrate the tissue for measurement of blood glucose.

And indeed, we are able to get these areas of the brain that were not using glucose to use glucose once again.

Vehicle utilization

Utilization rate

And in case you care about things like word origins, glucose comes from, the gluc part of glucose comes from Greek for sweet.

So cellular respiration, for every mole of a glucose,

They're saying, hey, we have 25 grams of glucose.

Or if we want to be specific, from glucose.

Glycolysis means we're going to be breaking up glucose.

Let me show you what glucose actually looks like.

I'll put glucose at top and oxygen down below.

Filesystem Utilization Viewer

COMBINED UTILIZATION FACTOR

per cent utilization

III. RESOURCE UTILIZATION