downgraded

I admit, is pretty disheartening.

This is indeed a depressing situation.

In molecular biology, elastase is an enzyme from the class of proteases (peptidases) that break down proteins.

Don't get discouraged, don't get upset.

Now, everything I've been telling you, I admit, is pretty disheartening.

Medicine It may be possible to exploit RNA interference in therapy.

The Committee's failure to agree on a text was disappointing.

Life in camps is demoralizing and ultimately dehumanizing.

The financial level at which the Global Environment Facility has been renegotiated is equally discouraging.

In aeronautics, a spoiler (sometimes called a lift dumper) is a device intended to reduce lift in an aircraft.

The presence of the Joint Unit for the Investigation of Illegal Armed Groups having Political Motivations may well have acted as a deterrent.

The triphosphate serves as a defective substrate for the NS5B protein, which is the viral RNA polymerase, thus acts as an inhibitor of viral RNA synthesis.

This leads to a chilling effect among those serving in the military public affairs field, who conclude that there is no tolerance for innovation.

This level of annual borrowing is far too high for comfort. It must be cut, but how?

That complexity might prove discouraging, and priority therefore should be given to considering ways to simplify the guidelines for the voluntary preparation of reports.

It led to a ban of this neuro toxic flame retardant called Deca in Maine, where I am based, and also then a phase out,

It is now known that the feeder cells provide leukemia inhibitory factor (LIF) and serum provides bone morphogenetic proteins (BMPs) that are necessary to prevent ES cells from differentiating.

It is a mild inhibitor of the formation of pigment in plant and animal tissues, and is used in food and cosmetics to preserve or change colors of substances.

It would also have a dampening impact on the long term prospects for reform in Belarus by creating an eastern bloc of Slavic nations suspicious of the West.

Patients with compensated congestive heart failure may be treated with bisoprolol as a comedication (usually with an ACE inhibitor, a diuretic, and a digitalis glycosid, if indicated).

Nothing is more detrimental to popular enthusiasm for change than to start with a burst of action followed by a long period of uncertainty and finally ending with few or no results.

Another approach is to use the 1 3 to 2 3 method mentioned above that is, to install a vapor retarder on the inside of the existing wall (if there isn't one there already) and add insulation and support structure to the inside.

This is itself a disincentive to report and leads to the need for the State to present additional information to update the report which, in turn, increases the volume of documentation that must be considered by the Committee.

This is discouraging, given reports in the media and on the Internet some of which may be incorrect, but certainly not all regarding the movement of various listed individuals.

The Thorough QT QTc study was designed to assess the effect on the QT QTc interval, both of the therapeutic dose (20 mg) and 100 mg of bilastine, but also the coadministration of the therapeutic dose with usual doses of ketoconazol (400 mg day), a metabolism inhibitor and a P gP dependent transport system.