The X ray revealed a small tumour for which he will undergo further tests.

After reviewing the proposed study, the Panel considers that the following modifications are necessary The study of testis tumours, retinoblastoma, neuroblastoma and Wilms tumour should be excluded.

When not utilizing frozen section, the surgeon might have to wait a week or more, before informing the patient if more tumour is left, or if the surgical margin is too narrow.

Plasmid encoding B7 1 (a ligand on APCs) has successfully enhanced the immune response in anti tumour models, and mixing plasmids encoding GM CSF and the circumsporozoite protein of P. yoelii (PyCSP) has enhanced protection against subsequent challenge (whereas plasmid encoded PyCSP alone did not).

In the first F4 report, the Panel noted that, for the types of cancers that Iran proposed to study, particularly solid tumour cancers, there was generally a latency period of 15 to 20 years between the time of the initial exposure to a given carcinogen and the first clinical evidence of cancer.

Testis tumours are unlikely to be associated with environmental factors while retinoblastoma, neuroblastoma and Wilms tumour are extremely rare and The statistical analysis using the DALY index should be excluded because the calculation is not necessary to complete the epidemiological investigation and because the results of the study will not be available to support any claim before the Commission.