They are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.

However, continued exposure to antigen through those low levels of immunoglobulin is important, as it partly determines the cell's lifespan.

In immunology, the immunoglobulin isotype refers to the genetic variations or differences in the constant regions of the heavy and light chains.

These antibodies, known as immunoglobulin A (IgA), make up the immune defense system of human by preventing the growth of harmful microorganisms in the body and by neutralizing toxins secreted by these microorganisms.

The name is an acronym deriving from some of the main features Polyneuropathy (peripheral nerve damage), Organomegaly (abnormal enlargement of organs), Endocrinopathy (damage to hormone producing glands) or Edema, M protein (an abnormal immunoglobulin) and Skin abnormalities (including hyperpigmentation and hypertrichosis).