This has led to analysis of chemical characteristics of combinatorial chemistry products, compared to existing drugs or natural products.

Despite the rise of combinatorial chemistry as an integral part of lead discovery process, natural products still play a major role as starting material for drug discovery.

However, now, after two decades of combinatorial chemistry, it has been pointed out that despite the increased efficiency in chemical synthesis, no increase in lead or drug candidates has been reached.

But the difference is that these cultures never expand, never grow, never accumulate, never become combinatorial, and the reason is because there is no sex, as it were, there is no exchange of ideas.

Within a short while, I think there's going to be a new field called Combinatorial Genomics, because with these new synthesis capabilities, these vast gene array repertoires and the homologous recombination, we think we can design a robot to make maybe a million different chromosomes a day.