The outbreak of bubonic plague in 1894 became a concern to the Hong Kong Government.

Early diseases that spread from Asia to Europe were bubonic plague, influenza of various types, and similar infectious disease.

During late 1896, a Bubonic plague spread from Bombay to Pune, and by January 1897, it reached epidemic proportions.

However, due to the wars of Charles XII of Sweden and bubonic plague epidemics, the population dropped to 1,500 by 1727.

Bubonic plague, or the Black Death, originated in Asia, but its spread killed a quarter to a third of Europe s population in the fourteenth century.

As with the pneumonic form of bubonic plague, it was associated with breakdown of lung tissue which would cause blood to appear at the lips.

Indeed, it is humbling to remember that some of history s most deadly invasions were carried out by single cell organisms, such as cholera, bubonic plague, and tuberculosis.

But the siege was hard not only on the inhabitants of Lisbon the army of Castile was also dealing with a shortage of food supplies, due to the harassment of Nuno Álvares Pereira, and the bubonic plague.

The plague was carried by fleas on sailing vessels returning from the ports of Asia, spreading quickly due to lack of proper sanitation the population of England, then about 4.2 million, lost 1.4 million people to the bubonic plague.